Calpain-Regulated p35/cdk5 Plays a Central Role in Dopaminergic Neuron Death through Modulation of the Transcription Factor Myocyte Enhancer Factor 2

The mechanisms underlying dopamine neuron loss in Parkinson's disease (PD) are not clearly defined. Here, we delineate a pathway by which dopaminergic loss induced by 1-methyl-4-phenyl 1,2,3,6 tetrahydropyridine (MPTP) is controlled in vivo. We reported previously that calpains play a central r...

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Bibliografiset tiedot
Julkaisussa:J Neurosci
Päätekijät: Smith, Patrice D., Mount, Matthew P., Shree, Raj, Callaghan, Steve, Slack, Ruth S., Anisman, Hymie, Vincent, Inez, Wang, Xuemin, Mao, Zixu, Park, David S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2006
Aiheet:
Neurobiology of Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674390/
https://ncbi.nlm.nih.gov/pubmed/16407541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2875-05.2006
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