Complete Dissociation of Motor Neuron Death from Motor Dysfunction by Bax Deletion in a Mouse Model of ALS

The death of cranial and spinal motoneurons (MNs) is believed to be an essential component of the pathogenesis of amyotrophic lateral sclerosis (ALS). We tested this hypothesis by crossing Bax-deficient mice with mice expressing mutant superoxide dismutase 1 (SOD1), a transgenic model of familial AL...

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Publicado no:J Neurosci
Main Authors: Gould, Thomas W., Buss, Robert R., Vinsant, Sharon, Prevette, David, Sun, Woong, Knudson, C. Michael, Milligan, Carol E., Oppenheim, Ronald W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674380/
https://ncbi.nlm.nih.gov/pubmed/16928866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2315-06.2006
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