Pathological Changes in Dopaminergic Nerve Cells of the Substantia Nigra and Olfactory Bulb in Mice Transgenic for Truncated Human α-Synuclein(1–120): Implications for Lewy Body Disorders

Dysfunction of the 140 aa protein α-synuclein plays a central role in Lewy body disorders, including Parkinson’s disease, as well as in multiple system atrophy. Here, we show that the expression of truncated human α-synuclein(1–120), driven by the rat tyrosine hydroxylase promoter on a mouse α-synuc...

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Pubblicato in:J Neurosci
Autori principali: Tofaris, George K., Garcia Reitböck, Pablo, Humby, Trevor, Lambourne, Sarah L., O’Connell, Mark, Ghetti, Bernardino, Gossage, Helen, Emson, Piers C., Wilkinson, Lawrence S., Goedert, Michel, Grazia Spillantini, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673887/
https://ncbi.nlm.nih.gov/pubmed/16611810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4965-05.2006
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