Autonomic Denervation of Lymphoid Organs Leads to Epigenetic Immune Atrophy in a Mouse Model of Krabbe Disease

Lysosomal β-galactosylceramidase deficiency results in demyelination and inflammation in the nervous system causing the neurological Krabbe disease. In the Twitcher mouse model of this disease, we found that neurological symptoms parallel progressive and severe lymphopenia. Although lymphopoiesis is...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Galbiati, Francesca, Basso, Veronica, Cantuti, Ludovico, Givogri, Maria Irene, Lopez-Rosas, Aurora, Perez, Nicolas, Vasu, Chenthamarakshan, Cao, Hongmei, van Breemen, Richard, Mondino, Anna, Bongarzone, Ernesto R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2007
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673629/
https://ncbi.nlm.nih.gov/pubmed/18077684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3379-07.2007
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