Autonomic Denervation of Lymphoid Organs Leads to Epigenetic Immune Atrophy in a Mouse Model of Krabbe Disease

Lysosomal β-galactosylceramidase deficiency results in demyelination and inflammation in the nervous system causing the neurological Krabbe disease. In the Twitcher mouse model of this disease, we found that neurological symptoms parallel progressive and severe lymphopenia. Although lymphopoiesis is...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Galbiati, Francesca, Basso, Veronica, Cantuti, Ludovico, Givogri, Maria Irene, Lopez-Rosas, Aurora, Perez, Nicolas, Vasu, Chenthamarakshan, Cao, Hongmei, van Breemen, Richard, Mondino, Anna, Bongarzone, Ernesto R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673629/
https://ncbi.nlm.nih.gov/pubmed/18077684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3379-07.2007
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