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p19(Ink4d) and p21(Cip1) Collaborate to Maintain the Postmitotic State of Auditory Hair Cells, Their Codeletion Leading to DNA Damage and p53-Mediated Apoptosis
Sensory hair cells of the auditory organ are generated during embryogenesis and remain postmitotic throughout life. Previous work has shown that inactivation of the cyclin-dependent kinase inhibitor (CKI) p19(Ink4d) leads to progressive hearing loss attributable to inappropriate DNA replication and...
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| Publicat a: | J Neurosci |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Society for Neuroscience
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6673588/ https://ncbi.nlm.nih.gov/pubmed/17287518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4956-06.2007 |
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