p19(Ink4d) and p21(Cip1) Collaborate to Maintain the Postmitotic State of Auditory Hair Cells, Their Codeletion Leading to DNA Damage and p53-Mediated Apoptosis

Sensory hair cells of the auditory organ are generated during embryogenesis and remain postmitotic throughout life. Previous work has shown that inactivation of the cyclin-dependent kinase inhibitor (CKI) p19(Ink4d) leads to progressive hearing loss attributable to inappropriate DNA replication and...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Laine, Heidi, Doetzlhofer, Angelika, Mantela, Johanna, Ylikoski, Jukka, Laiho, Marikki, Roussel, Martine F., Segil, Neil, Pirvola, Ulla
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673588/
https://ncbi.nlm.nih.gov/pubmed/17287518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4956-06.2007
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