Angiotensin-Converting Enzyme Converts Amyloid β-Protein 1–42 (Aβ(1–42)) to Aβ(1–40), and Its Inhibition Enhances Brain Aβ Deposition

The abnormal deposition of the amyloid β-protein (Aβ) in the brain appears crucial to the pathogenesis of Alzheimer's disease (AD). Recent studies have suggested that highly amyloidogenic Aβ(1–42) is a cause of neuronal damage leading to AD pathogenesis and that monomeric Aβ(1–40) has less neur...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Zou, Kun, Yamaguchi, Haruyasu, Akatsu, Hiroyasu, Sakamoto, Takaaki, Ko, Mihee, Mizoguchi, Kazushige, Gong, Jian-Sheng, Yu, Wenxin, Yamamoto, Takayuki, Kosaka, Kenji, Yanagisawa, Katsuhiko, Michikawa, Makoto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2007
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672927/
https://ncbi.nlm.nih.gov/pubmed/17687040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1549-07.2007
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