Bim Is Elevated in Alzheimer's Disease Neurons and Is Required for β-Amyloid-Induced Neuronal Apoptosis

The molecules that mediate neuron death in Alzheimer's disease (AD) are largely unknown. We report that β-amyloid (Aβ), a death-promoting peptide implicated in the pathophysiology of AD, induces the proapoptotic protein Bcl-2 interacting mediator of cell death (Bim) in cultured hippocampal and...

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Published in:J Neurosci
Main Authors: Biswas, Subhas C., Shi, Yijie, Vonsattel, Jean-Paul G., Leung, Conrad L., Troy, Carol M., Greene, Lloyd A.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672914/
https://ncbi.nlm.nih.gov/pubmed/17251431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3524-06.2007
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