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Bim Is Elevated in Alzheimer's Disease Neurons and Is Required for β-Amyloid-Induced Neuronal Apoptosis
The molecules that mediate neuron death in Alzheimer's disease (AD) are largely unknown. We report that β-amyloid (Aβ), a death-promoting peptide implicated in the pathophysiology of AD, induces the proapoptotic protein Bcl-2 interacting mediator of cell death (Bim) in cultured hippocampal and...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6672914/ https://ncbi.nlm.nih.gov/pubmed/17251431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3524-06.2007 |
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