The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice

It is well established that the proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid (Aβ), which plays a central role in the pathogenesis of Alzheimer's disease (AD). In contrast, the physiological role of APP and of its numerous proteolytic fragments and the ques...

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Vydáno v:J Neurosci
Hlavní autoři: Ring, Sabine, Weyer, Sascha W., Kilian, Susanne B., Waldron, Elaine, Pietrzik, Claus U., Filippov, Mikhail A., Herms, Jochen, Buchholz, Christian, Eckman, Christopher B., Korte, Martin, Wolfer, David P., Müller, Ulrike C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672885/
https://ncbi.nlm.nih.gov/pubmed/17634375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1026-07.2007
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