Pharmacological Imposition of Sleep Slows Cognitive Decline and Reverses Dysregulation of Circadian Gene Expression in a Transgenic Mouse Model of Huntington's Disease

Transgenic R6/2 mice carrying the Huntington's disease (HD) mutation show disrupted circadian rhythms that worsen as the disease progresses. By 15 weeks of age, their abnormal circadian behavior mirrors that seen in HD patients and is accompanied by dysregulated clock gene expression in the cir...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Pallier, Patrick N., Maywood, Elizabeth S., Zheng, Zhiguang, Chesham, Johanna E., Inyushkin, Alexei N., Dyball, Richard, Hastings, Michael H., Jennifer Morton, A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2007
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672877/
https://ncbi.nlm.nih.gov/pubmed/17634381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0649-07.2007
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