cAMP-Dependent Signalling as a Core Component of the Mammalian Circadian Pacemaker

The mammalian circadian clockwork is modelled as transcriptional and post-translational feedback loops, whereby circadian genes are periodically suppressed by their protein products. We show that adenosine 3′5′ monophosphate (cAMP) signalling constitutes an additional, bona fide component of the osc...

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Bibliographic Details
Main Authors: O’Neill, John S., Maywood, Elizabeth S., Chesham, Johanna E., Takahashi, Joseph S., Hastings, Michael H.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735813/
https://ncbi.nlm.nih.gov/pubmed/18487196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1152506
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