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cAMP-Dependent Signalling as a Core Component of the Mammalian Circadian Pacemaker

The mammalian circadian clockwork is modelled as transcriptional and post-translational feedback loops, whereby circadian genes are periodically suppressed by their protein products. We show that adenosine 3′5′ monophosphate (cAMP) signalling constitutes an additional, bona fide component of the osc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: O’Neill, John S., Maywood, Elizabeth S., Chesham, Johanna E., Takahashi, Joseph S., Hastings, Michael H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735813/
https://ncbi.nlm.nih.gov/pubmed/18487196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1152506
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