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Brain-Derived Neurotrophic Factor Expression and Respiratory Function Improve after Ampakine Treatment in a Mouse Model of Rett Syndrome

Rett syndrome (RTT) is caused by loss-of-function mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2). Although MeCP2 is thought to act as a transcriptional repressor of brain-derived neurotrophic factor (BDNF), Mecp2 null mice, which develop an RTT-like phenotype, exhibit progressiv...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ogier, Michael, Wang, Hong, Hong, Elizabeth, Wang, Qifang, Greenberg, Michael E., Katz, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672830/
https://ncbi.nlm.nih.gov/pubmed/17913925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1869-07.2007
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