Reduced Vesicular Storage of Dopamine Causes Progressive Nigrostriatal Neurodegeneration

The vesicular monoamine transporter 2 (VMAT2; SLC18A2) is responsible for packaging dopamine into vesicles for subsequent release and has been suggested to serve a neuroprotective role in the dopamine system. Here, we show that mice that express ∼5% of normal VMAT2 (VMAT2 LO) display age-associated...

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Publicado en:J Neurosci
Main Authors: Caudle, W. Michael, Richardson, Jason R., Wang, Min Z., Taylor, Tonya N., Guillot, Thomas S., McCormack, Alison L., Colebrooke, Rebecca E., Di Monte, Donato A., Emson, Piers C., Miller, Gary W.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2007
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672727/
https://ncbi.nlm.nih.gov/pubmed/17652604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0319-07.2007
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