The Functional Impact of the Intrastriatal Dopamine Neuron Grafts in Parkinsonian Rats Is Reduced with Advancing Disease

Clinical trials involving intrastriatal transplants of human embryonic mesencephalic tissue have provided proof-of-principle that nigral dopamine (DA) neurons can survive and functionally integrate into the host neural circuitry. However, the degree of graft-induced symptomatic relief differs signif...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Breysse, Nathalie, Carlsson, Thomas, Winkler, Christian, Björklund, Anders, Kirik, Deniz
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672262/
https://ncbi.nlm.nih.gov/pubmed/17537955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0626-07.2007
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