Lack of Hypoxia-Inducible Factor-1α Impairs Midbrain Neural Precursor Cells Involving Vascular Endothelial Growth Factor Signaling

Oxygen tension is critical for proliferation of human and murine midbrain-derived neural precursor cells (mNPCs). Here, we conditionally inactivated the hypoxia-responsive transcription factor hypoxia-inducible factor-1α (HIF-1α) in murine NPCs to determine its role in proliferation, survival, and d...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Milosevic, Javorina, Maisel, Martina, Wegner, Florian, Leuchtenberger, Julia, Wenger, Roland H., Gerlach, Manfred, Storch, Alexander, Schwarz, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672078/
https://ncbi.nlm.nih.gov/pubmed/17215402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2482-06.2007
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