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ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator of TG catabolism. We recently established that in vivo apoC-III predomin...

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Bibliografische gegevens
Gepubliceerd in:J Lipid Res
Hoofdauteurs: Ramms, Bastian, Patel, Sohan, Nora, Chelsea, Pessentheiner, Ariane R., Chang, Max W., Green, Courtney R., Golden, Gregory J., Secrest, Patrick, Krauss, Ronald M., Metallo, Christian M., Benner, Christopher, Alexander, Veronica J., Witztum, Joseph L., Tsimikas, Sotirios, Esko, Jeffrey D., Gordts, Philip L. S. M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Biochemistry and Molecular Biology 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672034/
https://ncbi.nlm.nih.gov/pubmed/31092690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M093740
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