ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator of TG catabolism. We recently established that in vivo apoC-III predomin...

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Udgivet i:J Lipid Res
Main Authors: Ramms, Bastian, Patel, Sohan, Nora, Chelsea, Pessentheiner, Ariane R., Chang, Max W., Green, Courtney R., Golden, Gregory J., Secrest, Patrick, Krauss, Ronald M., Metallo, Christian M., Benner, Christopher, Alexander, Veronica J., Witztum, Joseph L., Tsimikas, Sotirios, Esko, Jeffrey D., Gordts, Philip L. S. M.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672034/
https://ncbi.nlm.nih.gov/pubmed/31092690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M093740
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