Rivaroxaban, a specific FXa inhibitor, improved endothelium-dependent relaxation of aortic segments in diabetic mice

Activated factor X (FXa) plays a central role in the coagulation cascade, while it also mediates vascular function through activation of protease-activated receptors (PARs). Here, we examined whether inhibition of FXa by rivaroxaban, a direct FXa inhibitor, attenuates endothelial dysfunction in stre...

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Pubblicato in:Sci Rep
Autori principali: Pham, Phuong Tran, Fukuda, Daiju, Yagi, Shusuke, Kusunose, Kenya, Yamada, Hirotsugu, Soeki, Takeshi, Shimabukuro, Michio, Sata, Masataka
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672013/
https://ncbi.nlm.nih.gov/pubmed/31371788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47474-0
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