(5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients

Tripterygium is a traditional Chinese medicine that has widely been used in the treatment of rheumatic disease. (5R)-5-hydroxytriptolide (LLDT-8) is an extracted compound from Tripterygium, which has been shown to have lower cytotoxicity and relatively higher immunosuppressive activity when compared...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Guo, Shicheng, Liu, Jia, Jiang, Ting, Lee, Dungyang, Wang, Rongsheng, Zhou, Xinpeng, Jin, Yehua, Shen, Yi, Wang, Yan, Bai, Fengmin, Ding, Qin, Wang, Grace, Zhang, Jianyong, Zhou, Xiaodong, Schrodi, Steven J., He, Dongyi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671973/
https://ncbi.nlm.nih.gov/pubmed/31371761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47411-1
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