An Aggregate-Inducing Peripherin Isoform Generated through Intron Retention Is Upregulated in Amyotrophic Lateral Sclerosis and Associated with Disease Pathology

The neuronal intermediate filament protein peripherin is a component of ubiquitinated inclusions and of axonal spheroids in amyotrophic lateral sclerosis (ALS). Overexpression of peripherin causes motor neuron degeneration in transgenic mice and variations within the peripherin gene have been identi...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Xiao, Shangxi, Tjostheim, Sonja, Sanelli, Teresa, McLean, Jesse R., Horne, Patrick, Fan, Yuxin, Ravits, John, Strong, Michael J., Robertson, Janice
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671437/
https://ncbi.nlm.nih.gov/pubmed/18287500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3222-07.2008
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