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An Aggregate-Inducing Peripherin Isoform Generated through Intron Retention Is Upregulated in Amyotrophic Lateral Sclerosis and Associated with Disease Pathology

The neuronal intermediate filament protein peripherin is a component of ubiquitinated inclusions and of axonal spheroids in amyotrophic lateral sclerosis (ALS). Overexpression of peripherin causes motor neuron degeneration in transgenic mice and variations within the peripherin gene have been identi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Xiao, Shangxi, Tjostheim, Sonja, Sanelli, Teresa, McLean, Jesse R., Horne, Patrick, Fan, Yuxin, Ravits, John, Strong, Michael J., Robertson, Janice
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671437/
https://ncbi.nlm.nih.gov/pubmed/18287500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3222-07.2008
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