Thromboxane Receptor Activation Mediates Isoprostane-Induced Increases in Amyloid Pathology in Tg2576 Mice

Alzheimer's disease (AD) amyloid plaques are composed of amyloid-β (Aβ) peptides produced from proteolytic cleavage of amyloid precursor protein (APP). Isoprostanes, markers of in vivo oxidative stress, are elevated in AD patients and in the Tg2576 mouse model of AD-like Aβ brain pathology. To...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Shineman, Diana W., Zhang, Bin, Leight, Susan N., Pratico, Domenico, Lee, Virginia M.-Y.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2008
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670429/
https://ncbi.nlm.nih.gov/pubmed/18448655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0684-08.2008
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