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In-vitro and in-vivo difference in gene delivery by lithocholic acid-polyethyleneimine conjugate

Polyethyleneimine (PEI) is widely used for the delivery of nucleic acids, but its clinical application is limited due to high cytotoxicity and instability in biological fluids. To overcome these challenges, linear PEI (2.5 kDa) was modified with lithocholic acid (LCA) to produce a LCA-PEI conjugate...

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Detalhes bibliográficos
Publicado no:Biomaterials
Main Authors: Wang, Jianping, Meng, Fanfei, Kim, Bieong-Kil, Ke, Xue, Yeo, Yoon
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670295/
https://ncbi.nlm.nih.gov/pubmed/31254934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2019.119296
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