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In-vitro and in-vivo difference in gene delivery by lithocholic acid-polyethyleneimine conjugate
Polyethyleneimine (PEI) is widely used for the delivery of nucleic acids, but its clinical application is limited due to high cytotoxicity and instability in biological fluids. To overcome these challenges, linear PEI (2.5 kDa) was modified with lithocholic acid (LCA) to produce a LCA-PEI conjugate...
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| Publicado en: | Biomaterials |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6670295/ https://ncbi.nlm.nih.gov/pubmed/31254934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2019.119296 |
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