DIVERSet JAG Compounds Inhibit Topoisomerase II and Are Effective Against Adult and Pediatric High-Grade Gliomas

High-grade gliomas (HGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis in both adult and pediatric patients. Clinical response is compounded by resistance to standard frontline antineoplastic agents, an absence of novel therapeutics, and poor in vitro mo...

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Dades bibliogràfiques
Publicat a:Transl Oncol
Autors principals: Howarth, Alison, Simms, Claire, Kerai, Nitesh, Allen, Olivia, Mihajluk, Karina, Madureira, Patricia A., Sokratous, Giannis, Cragg, Simon, Lee, Sang Y., Morley, Andy D., Ashkan, Keyoumars, Cox, Paul A., Pilkington, Geoffrey J., Hill, Richard
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press 2019
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Original article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669375/
https://ncbi.nlm.nih.gov/pubmed/31374406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.07.007
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