DIVERSet JAG Compounds Inhibit Topoisomerase II and Are Effective Against Adult and Pediatric High-Grade Gliomas

High-grade gliomas (HGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis in both adult and pediatric patients. Clinical response is compounded by resistance to standard frontline antineoplastic agents, an absence of novel therapeutics, and poor in vitro mo...

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Vydáno v:Transl Oncol
Hlavní autoři: Howarth, Alison, Simms, Claire, Kerai, Nitesh, Allen, Olivia, Mihajluk, Karina, Madureira, Patricia A., Sokratous, Giannis, Cragg, Simon, Lee, Sang Y., Morley, Andy D., Ashkan, Keyoumars, Cox, Paul A., Pilkington, Geoffrey J., Hill, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2019
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Original article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669375/
https://ncbi.nlm.nih.gov/pubmed/31374406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.07.007
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