DIVERSet JAG Compounds Inhibit Topoisomerase II and Are Effective Against Adult and Pediatric High-Grade Gliomas

High-grade gliomas (HGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis in both adult and pediatric patients. Clinical response is compounded by resistance to standard frontline antineoplastic agents, an absence of novel therapeutics, and poor in vitro mo...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Howarth, Alison, Simms, Claire, Kerai, Nitesh, Allen, Olivia, Mihajluk, Karina, Madureira, Patricia A., Sokratous, Giannis, Cragg, Simon, Lee, Sang Y., Morley, Andy D., Ashkan, Keyoumars, Cox, Paul A., Pilkington, Geoffrey J., Hill, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2019
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669375/
https://ncbi.nlm.nih.gov/pubmed/31374406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.07.007
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