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Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain
Signaling through the receptor tyrosine kinase RET is essential during normal development. Both gain- and loss-of-function mutations are involved in a variety of diseases, yet the molecular details of receptor activation have remained elusive. We have reconstituted the complete extracellular region...
Gorde:
| Argitaratua izan da: | Sci Adv |
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| Egile Nagusiak: | , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Association for the Advancement of Science
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6669014/ https://ncbi.nlm.nih.gov/pubmed/31392261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau4202 |
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