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Recombinant vector vaccine evolution

Replicating recombinant vector vaccines consist of a fully competent viral vector backbone engineered to express an antigen from a foreign transgene. From the perspective of viral replication, the transgene is not only dispensable but may even be detrimental. Thus vaccine revertants that delete or i...

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Bibliografische gegevens
Gepubliceerd in:PLoS Comput Biol
Hoofdauteurs: Bull, James J., Nuismer, Scott L., Antia, Rustom
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668849/
https://ncbi.nlm.nih.gov/pubmed/31323032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006857
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