Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations

Lumen integrity in vascularization requires fully differentiated endothelial cells (ECs). Here, we report that endothelial-mesenchymal transitions (EndMTs) emerged in ECs of cerebral arteriovenous malformation (AVMs) and caused disruption of the lumen or lumen disorder. We show that excessive Sry-bo...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Yao, Jiayi, Wu, Xiuju, Zhang, Daoqin, Wang, Lumin, Zhang, Li, Reynolds, Eric X., Hernandez, Carlos, Boström, Kristina I., Yao, Yucheng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2019
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668698/
https://ncbi.nlm.nih.gov/pubmed/31232700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125965
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items