Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations

Lumen integrity in vascularization requires fully differentiated endothelial cells (ECs). Here, we report that endothelial-mesenchymal transitions (EndMTs) emerged in ECs of cerebral arteriovenous malformation (AVMs) and caused disruption of the lumen or lumen disorder. We show that excessive Sry-bo...

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Publicat a:J Clin Invest
Autors principals: Yao, Jiayi, Wu, Xiuju, Zhang, Daoqin, Wang, Lumin, Zhang, Li, Reynolds, Eric X., Hernandez, Carlos, Boström, Kristina I., Yao, Yucheng
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668698/
https://ncbi.nlm.nih.gov/pubmed/31232700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125965
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