Fra-2–expressing macrophages promote lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is a deadly disease with limited therapies. Tissue fibrosis is associated with type 2 immune response, although the causal contribution of immune cells is not defined. The AP-1 transcription factor Fra-2 is upregulated in IPF lung sections, and Fra-2 transgenic mi...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Ucero, Alvaro C., Bakiri, Latifa, Roediger, Ben, Suzuki, Masakatsu, Jimenez, Maria, Mandal, Pratyusha, Braghetta, Paola, Bonaldo, Paolo, Paz-Ares, Luis, Fustero-Torre, Coral, Ximenez-Embun, Pilar, Hernandez, Ana Isabel, Megias, Diego, Wagner, Erwin F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668681/
https://ncbi.nlm.nih.gov/pubmed/31135379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125366
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