Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production

The activator protein-1 (AP-1) transcription factor complex, in particular the Fos proteins, is an important regulator of bone homeostasis. Fra-2 (Fosl2), a Fos-related protein of the AP-1 family, is expressed in bone cells, and newborn mice lacking Fra-2 exhibit defects in chondrocytes and osteocla...

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Autors principals: Bozec, Aline, Bakiri, Latifa, Jimenez, Maria, Schinke, Thorsten, Amling, Michael, Wagner, Erwin F.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2010
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101588/
https://ncbi.nlm.nih.gov/pubmed/20837772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201002111
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