Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35

Acute liver failure (ALF) is a life-threatening condition, and liver transplantation is the only therapeutic option. Although immune dysregulation is central to its pathogenesis, the precise mechanism remains unclear. Here, we show that the number of peripheral and hepatic plasmacytoid DCs (pDCs) de...

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Vydáno v:J Clin Invest
Hlavní autoři: Koda, Yuzo, Nakamoto, Nobuhiro, Chu, Po-Sung, Ugamura, Aya, Mikami, Yohei, Teratani, Toshiaki, Tsujikawa, Hanako, Shiba, Shunsuke, Taniki, Nobuhito, Sujino, Tomohisa, Miyamoto, Kentaro, Suzuki, Takahiro, Yamaguchi, Akihiro, Morikawa, Rei, Sato, Katsuaki, Sakamoto, Michiie, Yoshimoto, Takayuki, Kanai, Takanori
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668669/
https://ncbi.nlm.nih.gov/pubmed/31264967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125863
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