Decreased BDNF Levels Are a Major Contributor to the Embryonic Phenotype of Huntingtin Knockdown Zebrafish

Huntington's disease (HD) is an autosomal dominant, neurodegenerative condition caused by a CAG trinucleotide repeat expansion that is translated into an abnormally long polyglutamine tract in the protein huntingtin. Genetic and transgenic studies suggest that the mutation causes disease predom...

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Pubblicato in:J Neurosci
Autori principali: Diekmann, Heike, Anichtchik, Oleg, Fleming, Angeleen, Futter, Marie, Goldsmith, Paul, Roach, Alan, Rubinsztein, David C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6666080/
https://ncbi.nlm.nih.gov/pubmed/19193881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6039-08.2009
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