Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors

BACKGROUND: Huntington’s disease is caused by expansion of a polyglutamine tract found in the amino-terminal of the ubiquitously expressed protein huntingtin. Well studied in its mutant form, huntingtin has a wide variety of normal functions, loss of which may also contribute to disease progression....

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Hlavní autoři: Futter, M, Diekmann, H, Schoenmakers, E, Sadiq, O, Chatterjee, K, Rubinsztein, D C
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2009
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696822/
https://ncbi.nlm.nih.gov/pubmed/19451134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2009.066399
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