γ-Secretase Inhibition Reduces Spine Density In Vivo via an Amyloid Precursor Protein-Dependent Pathway

Alzheimer's disease (AD) represents the most common age-related neurodegenerative disorder. It is characterized by the invariant accumulation of the β-amyloid peptide (Aβ), which mediates synapse loss and cognitive impairment in AD. Current therapeutic approaches concentrate on reducing Aβ leve...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Bittner, Tobias, Fuhrmann, Martin, Burgold, Steffen, Jung, Christian K. E., Volbracht, Christiane, Steiner, Harald, Mitteregger, Gerda, Kretzschmar, Hans A., Haass, Christian, Herms, Jochen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2009
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665795/
https://ncbi.nlm.nih.gov/pubmed/19692615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2288-09.2009
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi