γ-Secretase Inhibition Reduces Spine Density In Vivo via an Amyloid Precursor Protein-Dependent Pathway

Alzheimer's disease (AD) represents the most common age-related neurodegenerative disorder. It is characterized by the invariant accumulation of the β-amyloid peptide (Aβ), which mediates synapse loss and cognitive impairment in AD. Current therapeutic approaches concentrate on reducing Aβ leve...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Bittner, Tobias, Fuhrmann, Martin, Burgold, Steffen, Jung, Christian K. E., Volbracht, Christiane, Steiner, Harald, Mitteregger, Gerda, Kretzschmar, Hans A., Haass, Christian, Herms, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665795/
https://ncbi.nlm.nih.gov/pubmed/19692615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2288-09.2009
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