Dissociating β-Amyloid from α7 Nicotinic Acetylcholine Receptor by a Novel Therapeutic Agent, S 24795, Normalizes α7 Nicotinic Acetylcholine and NMDA Receptor Function in Alzheimer's Disease Brain

Alzheimer's disease (AD) is characterized by synaptic dysfunction and cardinal neuropathological features including amyloid plaques and neurofibrillary tangles. Soluble amyloid-β (Aβ) can suppress synaptic activities by interacting with α7 nicotinic acetylcholine receptors (α7nAChRs). Here, we...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Wang, Hoau-Yan, Stucky, Andres, Liu, JingJing, Shen, Changpeng, Trocme-Thibierge, Caryn, Morain, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665534/
https://ncbi.nlm.nih.gov/pubmed/19726654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6088-08.2009
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