Dissociating β-Amyloid from α7 Nicotinic Acetylcholine Receptor by a Novel Therapeutic Agent, S 24795, Normalizes α7 Nicotinic Acetylcholine and NMDA Receptor Function in Alzheimer's Disease Brain

Alzheimer's disease (AD) is characterized by synaptic dysfunction and cardinal neuropathological features including amyloid plaques and neurofibrillary tangles. Soluble amyloid-β (Aβ) can suppress synaptic activities by interacting with α7 nicotinic acetylcholine receptors (α7nAChRs). Here, we...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Wang, Hoau-Yan, Stucky, Andres, Liu, JingJing, Shen, Changpeng, Trocme-Thibierge, Caryn, Morain, Philippe
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2009
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665534/
https://ncbi.nlm.nih.gov/pubmed/19726654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6088-08.2009
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