Dissociating β-Amyloid from α7 Nicotinic Acetylcholine Receptor by a Novel Therapeutic Agent, S 24795, Normalizes α7 Nicotinic Acetylcholine and NMDA Receptor Function in Alzheimer's Disease Brain

Alzheimer's disease (AD) is characterized by synaptic dysfunction and cardinal neuropathological features including amyloid plaques and neurofibrillary tangles. Soluble amyloid-β (Aβ) can suppress synaptic activities by interacting with α7 nicotinic acetylcholine receptors (α7nAChRs). Here, we...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Wang, Hoau-Yan, Stucky, Andres, Liu, JingJing, Shen, Changpeng, Trocme-Thibierge, Caryn, Morain, Philippe
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2009
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665534/
https://ncbi.nlm.nih.gov/pubmed/19726654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6088-08.2009
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