Inhibitor κB Kinase β Deficiency in Primary Nociceptive Neurons Increases TRP Channel Sensitivity

Inhibitor κB kinase (IKK) regulates the activity of the transcription factor nuclear factor-κ B that normally protects neurons against excitotoxicity. Constitutively active IKK is enriched at axon initial segments and nodes of Ranvier (NR). We used mice with a Cre–loxP-mediated specific deletion of...

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Udgivet i:J Neurosci
Main Authors: Bockhart, Vanessa, Constantin, Cristina Elena, Häussler, Annett, Wijnvoord, Nina, Kanngiesser, Maike, Myrczek, Thekla, Pickert, Geethanjali, Popp, Laura, Sobotzik, Jürgen-Markus, Pasparakis, Manolis, Kuner, Rohini, Geisslinger, Gerd, Schultz, Christian, Kress, Michaela, Tegeder, Irmgard
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2009
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665282/
https://ncbi.nlm.nih.gov/pubmed/19828806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1496-09.2009
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