R-Flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids

BACKGROUND: R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear. METHODOLOGY/PRINCIPAL FINDINGS: We show that R-flurbiprofen reduces gluta...

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Detalhes bibliográficos
Main Authors: Bishay, Philipp, Schmidt, Helmut, Marian, Claudiu, Häussler, Annett, Wijnvoord, Nina, Ziebell, Simone, Metzner, Julia, Koch, Marco, Myrczek, Thekla, Bechmann, Ingo, Kuner, Rohini, Costigan, Michael, Dehghani, Faramarz, Geisslinger, Gerd, Tegeder, Irmgard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869361/
https://ncbi.nlm.nih.gov/pubmed/20498712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010628
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