Collagenolytic matrix metalloproteinases antagonize proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover

The collagenase subfamily of matrix metalloproteinases (MMPs) have important roles in the remodeling of collagenous matrices. The proteinase-activated receptor (PAR) family has a unique mechanism of activation requiring proteolysis of an extracellular domain forming a neo-N terminus that acts as a t...

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Vydáno v:J Biol Chem
Hlavní autoři: Falconer, Adrian M. D., Chan, Chun Ming, Gray, Joseph, Nagashima, Izuru, Holland, Robert A., Shimizu, Hiroki, Pickford, Andrew R., Rowan, Andrew D., Wilkinson, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664178/
https://ncbi.nlm.nih.gov/pubmed/31110047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.006974
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