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Structural analysis of a Vibrio phospholipase reveals an unusual Ser–His–chloride catalytic triad

Phospholipases can disrupt host membranes and are important virulence factors in many pathogens. VvPlpA is a phospholipase A(2) secreted by Vibrio vulnificus and essential for virulence. Its homologs, termed thermolabile hemolysins (TLHs), are widely distributed in Vibrio bacteria, but no structural...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Wan, Ye, Liu, Changshui, Ma, Qingjun
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663882/
https://ncbi.nlm.nih.gov/pubmed/31073025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008280
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