Atorvastatin restricts the ability of influenza virus to generate lipid droplets and severely suppresses the replication of the virus

Influenza virus causes infected cells to generate large numbers of lipid droplets. Because the virus envelope contains substantial cholesterol, we applied atorvastatin (ATV) to Madin-Darby Canine Kidney cells before infecting them. Five micromolars ATV, within physiologic range, strongly (>95%) i...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Episcopio, Donna, Aminov, Sarah, Benjamin, Shawna, Germain, Gabrielle, Datan, Emmanuel, Landazuri, Joselyn, Lockshin, Richard A., Zakeri, Zahra
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662987/
https://ncbi.nlm.nih.gov/pubmed/31125254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900428RR
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