Glycocalyx regulation of vascular endothelial growth factor receptor 2 activity

We have previously shown that knockdown of endomucin (EMCN), an integral membrane glycocalyx glycoprotein, prevents VEGF-induced proliferation, migration, and tube formation in vitro and angiogenesis in vivo. In the endothelium, VEGF mediates most of its angiogenic effects through VEGF receptor 2 (V...

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Veröffentlicht in:FASEB J
Hauptverfasser: LeBlanc, Michelle E., Saez-Torres, Kahira L., Cano, Issahy, Hu, Zhengping, Saint-Geniez, Magali, Ng, Yin-Shan, D’Amore, Patricia A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662976/
https://ncbi.nlm.nih.gov/pubmed/31141406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900011R
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