Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

Severe acute respiratory syndrome coronavirus (SARS-CoV) is capable of inducing a storm of proinflammatory cytokines. In this study, we show that the SARS-CoV open reading frame 3a (ORF3a) accessory protein activates the NLRP3 inflammasome by promoting TNF receptor-associated factor 3 (TRAF3)–mediat...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Siu, Kam-Leung, Yuen, Kit-San, Castaño-Rodriguez, Carlos, Ye, Zi-Wei, Yeung, Man-Lung, Fung, Sin-Yee, Yuan, Shuofeng, Chan, Chi-Ping, Yuen, Kwok-Yung, Enjuanes, Luis, Jin, Dong-Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662968/
https://ncbi.nlm.nih.gov/pubmed/31034780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802418R
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