A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1

The rapidly accelerated fibrosarcoma (Raf) kinase is canonically activated by growth factors that regulate multiple cellular processes. In this kinase cascade Raf activation ultimately results in extracellular regulated kinase 1/2 (Erk1/2) activation, which requires Ras binding to the Ras binding do...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Park, Sung Wook, Nhieu, Jennifer, Persaud, Shawna D., Miller, Michelle C., Xia, Youlin, Lin, Yi-Wei, Lin, Yu-Lung, Kagechika, Hiroyuki, Mayo, Kevin H., Wei, Li-Na
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662813/
https://ncbi.nlm.nih.gov/pubmed/31358819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47354-7
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