A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1

The rapidly accelerated fibrosarcoma (Raf) kinase is canonically activated by growth factors that regulate multiple cellular processes. In this kinase cascade Raf activation ultimately results in extracellular regulated kinase 1/2 (Erk1/2) activation, which requires Ras binding to the Ras binding do...

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Publicado en:Sci Rep
Autores principales: Park, Sung Wook, Nhieu, Jennifer, Persaud, Shawna D., Miller, Michelle C., Xia, Youlin, Lin, Yi-Wei, Lin, Yu-Lung, Kagechika, Hiroyuki, Mayo, Kevin H., Wei, Li-Na
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662813/
https://ncbi.nlm.nih.gov/pubmed/31358819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47354-7
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