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Roles of matricellular CCN2 deposited by osteocytes in osteoclastogenesis and osteoblast differentiation

In this study, we investigated the effect of CCN2 (cellular communication network factor 2), previously termed connective tissue growth factor, deposited in bone matrix on osteoclastogenesis and osteoblast differentiation. To mimic the bone matrix environment, osteocytic MLO-Y4 cells had been embedd...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Nishida, Takashi, Kubota, Satoshi, Yokoi, Hideki, Mukoyama, Masashi, Takigawa, Masaharu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662664/
https://ncbi.nlm.nih.gov/pubmed/31358778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47285-3
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