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Roles of matricellular CCN2 deposited by osteocytes in osteoclastogenesis and osteoblast differentiation

In this study, we investigated the effect of CCN2 (cellular communication network factor 2), previously termed connective tissue growth factor, deposited in bone matrix on osteoclastogenesis and osteoblast differentiation. To mimic the bone matrix environment, osteocytic MLO-Y4 cells had been embedd...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Nishida, Takashi, Kubota, Satoshi, Yokoi, Hideki, Mukoyama, Masashi, Takigawa, Masaharu
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662664/
https://ncbi.nlm.nih.gov/pubmed/31358778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47285-3
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